Living with chronic eye pain can be challenging, but you don’t have to face it alone.

Welcome to The Chronic Ocular Surface Pain (COSP) Study! Join our community of doctors, researchers, and patients dedicated to finding new treatments for eye pain.

The goal of this study is to see if an experimental cooling device (ETX-4143) is safe and effective in improving eye pain in adults with COSP. ETX-4143 may help improve symptoms related to ocular surface pain by temporarily reducing the intensity of painful nerve stimuli.

Participants who qualify will be asked to complete 8 study visits, including the procedure and follow-up appointments.

See if you qualify

You may be able to join the study if the following apply to you:

You are 21 years of age or older

You have a history of chronic ocular surface pain

Your symptoms improve with the use of topical anesthetic drops

Find out if you’re eligible

Other criteria may apply.

Eligible study participants will:

Be connected with their nearest study site.
Receive study information, and learn more about COSP and the clinical trial process.
Undergo health assessments and study procedures at no cost to them.
Receive assigned study treatment at no cost to them.
Be compensated for completing all clinic visits.
Meet with a research team 3 times in-person and 6 times virtually over an 8-week period.

See if you qualify

About Chronic Ocular Surface Pain (COSP)

Chronic eye pain, also known as chronic ocular surface pain (COSP), is the sensation of pain perceived as originating on the surface of the eye. It’s generally considered chronic if it has persisted for at least three months.

COSP may have various symptoms, such as dryness, discomfort, grittiness, itchiness, burning, stabbing, shooting, light sensitivity, or aching pain.

COSP can have a variety of causes, including but not limited to, long-term contact lens use, infection, prior ocular surgery or other trauma to the eye, nerve damage, or environmental factors such as airborne particles or exposure to toxins.

See if you qualify

Frequently Asked Questions

What is a research study?

Medical research studies help doctors and scientists learn about experimental treatments, including how well they work and how safe they are. Clinical trials may study the experimental treatment or device, and compare it to an approved medication or placebo.

What should I expect if I join this study?

There are common assessments that are performed during most clinical studies. Here is what you can expect during the ETX-4143 study:

1. Read and sign the Participant Informed Consent Form (PICF)

The PICF explains the study in more detail. The study doctor will explain the information in the PICF and answer any questions.
You must sign the PICF before receiving any study treatment or assessments.
Remember that taking part in the study is your choice. You can stop at any time.

2. Confirm that you can join the study

Participants who would like to join the study will undergo screening to ensure they are a good fit for the study. Study assessments/procedures may include:
- Demographics: You will be asked to provide personal information, including date of birth, gender, ethnic origins, and race (demographics).
- Medical History: You will be asked about your past and present health conditions, including chronic ocular pain. You must provide accurate and complete information about your medical history and present health conditions.
- Physical Exam: You will have physical examinations, including assessments of your pupils as well as standard visual imaging and testing.

3. Receive Assigned Study Treatment

If you meet the study requirements and you agree to participate by signing the Patient Informed Consent From (PICF), you will officially be enrolled in the study. Two-thirds of enrolled participants will receive the test product (called the ETX-4143 2.0 Device), and the remaining third will undergo a sham (or placebo) procedure.

The treatment application each time is from 2 to 6 minutes.

4. Visit the study clinic

Eligible participants will be asked to complete 3 in-person study visits and 6 virtual visits over an 8-week period.

Where are the study sites located?

Sites information:

Brisbane: Ophthalmic Trials Australia. Suite 2/53 Commercial Rd, Teneriffe QLD 4005, Australia
Sydney: The Westmead Institute for Medical Research. 176 Hawkesbury Rd, Westmead NSW 2145, Australia

How long will this study last?

Participation in the ETX-4143 study will last about 8 weeks.

Do I have to pay to join a clinical study?

No, you do not have to pay to participate in a clinical study.

Eligible participants will receive compensation for time and travel.
It does not cost any money to join this clinical study, and you do not need health insurance to join.
The study-related procedure and study visits will be of no cost to you or your insurance company.

How do I sign up?

To find out if you’re eligible to participate in this study, take this quick pre-screening form here.

Help advance eye pain research today!

Find out if you qualify

Additional Information

Participating in a clinical trial may involve unforeseeable risks and does not guarantee that your symptoms improve.

The study device treatment is investigational. This means it can only be used in research studies. It has not been approved by regulatory agencies as a therapy for chronic ocular pain.